Estradiol and Progesterone Creams
From $75 for a 30-day supply
Estradiol cream delivers bioidentical estrogen through gentle topical application, which bypasses the digestive system, eliminating potential stomach upset and reducing first-pass liver metabolism. Like transdermal patches, estradiol cream application may reduce certain risks associated with oral estrogen therapy, including blood clot formation.
Progesterone cream provides bioidentical progesterone through topical application for patients who cannot tolerate a capsule.
A combination cream delivers both hormones in a single topical application, streamlining hormone replacement therapy into one formulation that simplifies your daily routine.
All three creams are available in customizable strengths to meet individual therapeutic needs.
A metered dispenser provides better accuracy, improved hygiene, and enhanced compliance compared to traditional tubes.
Compounded drugs are permitted to be prescribed under federal law but are not FDA-approved. For more information on side effects and other safety information, see full important safety information for estradiol cream, progesterone cream, and the combination cream.
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FAQs
Topical application delivers hormones through the skin directly into the bloodstream, bypassing the digestive system entirely. This means no potential stomach upset and, importantly, no first-pass liver metabolism, which is the process by which oral medications are processed through the liver before reaching circulation. Avoiding this first-pass effect may reduce certain risks associated with oral estrogen therapy, including effects on clotting factors that can increase the risk of blood clot formation. Transdermal delivery also tends to provide more stable hormone levels throughout the day compared to oral formulations, which can reduce fluctuations that can effect mood swings, headaches, and trigger migraines.
Yes. Both the estradiol and progesterone in these creams are bioidentical, meaning their molecular structure is identical to the hormones your body naturally produced before menopause. The estradiol used in today's hormone therapy is derived from plant sources — typically wild yam or soy — and processed to match the estradiol your ovaries once made. This is different from older hormone formulations. Bioidentical does not mean unregulated or "natural" in the sense that it is found in nature. All of these creams are prescription medications prepared to precise clinical standards.
These terms are sometimes used interchangeably, but they refer to different things. Progesterone is the natural hormone your body produced before menopause; it's bioidentical, meaning its molecular structure matches what your body makes. Progestins, by contrast, are synthetic compounds designed to mimic progesterone's effects but with a different molecular structure. The most well-known progestin, medroxyprogesterone acetate (MPA, sold as Provera), was the form used in the Women's Health Initiative study in the early 2000s. Research since then suggests it may behave differently in the body than natural progesterone. At Inflexxion Health, we prescribe bioidentical micronized progesterone, which studies indicate has a more favorable safety profile.