Estrogen Patch

 Your estradiol patch is a fully FDA-approved, commercially manufactured medication. It is not formulated or produced by our compounding pharmacy partner. We work with a compounding pharmacy to fulfill prescriptions because it allows us to ship all of your medications together in one convenient package. This means you receive your patch alongside any other prescribed treatments (such as vaginal estrogen cream or testosterone cream) in a single shipment, rather than managing multiple pharmacies and deliveries. 

Yes. That's one of the reasons we prefer it. Estradiol is bioidentical, meaning its molecular structure is identical to the estradiol your ovaries naturally produced before menopause. This is different from older hormone formulations. Today's estradiol is derived from plant sources, such as wild yam, and processed to match the hormone your body knows well. 

Transdermal patches deliver estradiol through the skin directly into the bloodstream, bypassing the liver. Oral estrogen, by contrast, is processed through the liver before it reaches circulation, which can affect how the body handles it and may influence cardiovascular risk factors like clotting proteins. Patches also provide more stable, consistent hormone levels throughout the day, which tends to reduce complaints like estrogen peaks that can trigger migraines.

That said, oral estrogen is absolutely an option we offer at Inflexxion Health. It is less expensive than the patch, and some women's skin doesn't tolerate transdermal patches or creams well. What matters most is that you have options: the right choice is one you make together with your clinician.

 Estradiol patches are typically applied to clean, dry skin on your lower abdomen, buttocks, or upper hip away from the waistband and on a site with minimal hair. Most patches are changed twice weekly (every three to four days), though some formulations are designed for once-weekly use. Your specific patch schedule will be noted in your prescription instructions. Rotating application sites helps prevent skin irritation. If a patch loosens or falls off, press it back firmly or contact our team for guidance.